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KMID : 0383820110710040254
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Tuberculosis and Respiratory Diseases
2011 Volume.71 No. 4 p.254 ~ p.258
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Lack of Association between the Klotho Gene and COPD
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Kim Woo-Jin
Oh Yeon-Mok
Kim Tae-Hyung
Lee Ji-Hyun
Kim Eun-Kyung
Lee Jin-Hwa
Lee Sang-Min
Shin Tae-Rim
Yoon Ho-Il
Lim Seong-Yong
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Abstract
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Background: Although the aging process and features of chronic obstructive pulmonary disease (COPD) have several similarities, the relationship between aging and COPD pathogenesis remains incompletely understood. The klotho gene was found to be related to premature aging and emphysematous changes in an animal model. We investigated whether klotho gene polymorphisms are related to COPD susceptibility and emphysema severity.
Materials and Methods : A total of 219 COPD subjects from the Korean Obstructive Lung Disease Cohort and 305 control subjects were genotyped for two single nucleotide polymorphisms (SNPs) of the klotho gene associated with coronary artery disease. Logistic regression was performed to determine the association of these SNPs with COPD susceptibility and linear regression was performed to investigate their association with emphysema severity in COPD subjects.
Results: The mean age of the COPD subjects was 66 years and their mean FEV1 was 1.46 L. There were no associations between either SNP or COPD susceptibility (p=0.6 and 0.2, respectively) and there were no associations with emphysema severity.
Conclusion: Genetic polymorphisms of the klotho gene were not associated with COPD in a Korean population.
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KEYWORD
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Pulmonary Disease, Chronic Obstructive, Polymorphism, Genetic
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